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Design changes in the second generation device using improved electronic components, circuit boards and digital signaling technology, resulted in reduced weight and increased operational efficiency for people with glioblastoma multiforme, improving the patient experience with TTFields treatment. (Top left, 1st generation Optune; Top Right, 2nd generation Optune; Bottom panels, patients wearing 2nd generation Optune with white and tan arrays).
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Based on the treatment success in GBM, TTFields are being investigated in a number of other solid tumours outside of the brain20. Phase II clinical trials have been completed in mesothelioma, ovarian cancer, NSCLC and pancreatic adenocarcinoma. Phase III trials are underway in pancreatic adenocarcinoma and NSCLC. The FDA has designated the TTFields delivery system as a humanitarian use device for the treatment of pleural mesothelioma.
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TTFields therapy causes minimal damage to healthy cells. Mild to moderate skin irritation is the most common side effect reported. TTFields therapy is approved in certain countries for the treatment of adults with glioblastoma, malignant pleural mesothelioma and pleural mesothelioma, some of the most difficult cancer types to treat. The therapy shows promise in multiple solid tumor types – including some of the most aggressive forms of cancer.
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S. CNS Cancers Franchise. “We are eager to engage with the neuro-oncology community as we strive to extend survival in some of the most aggressive forms of cancer.”